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Associations of Homocysteine, Folate, and Vitamin B12 with Osteoarthritis: A Mendelian Randomization Study

Butyrate, in particular, inhibits HDAC3, reduces mTOR activation and glycolysis, enhances macrophage bactericidal activity, and promotes an anti-inflammatory phenotype (92)

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The broader relevance of these findings extends beyond TMAU, since elevated TMAO is a well-established risk factor for atherosclerosis, thrombosis, and major adverse cardiac events (Tang et al., 2013