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This can be problematic for people with Graves disease, as muscle weakness is already a common symptom of the condition

Starting at higher doses does not produce faster weight lossresearch shows it only increases nausea, vomiting, and dropout rates

In vivo , apigenin reduces the secretion of pro-inflammatory factors (IL-1, IL-6, and TNF-), reduces the expression of the DCs costimulatory molecules CXCR4 and MHCII, and reduces the number of Langerhans cells

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