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This oxidative stress plays a central role in disease progression from simple steatosis to more serious conditions such as non-alcoholic steatohepatitis (NASH), fibrosis, and potentially cirrhosis

Again, the loss of correlations in the pathway metabolite may be lost in patients due to illness-related, and also perhaps treatment influences, on 5-HIAA, since the TRP5-HIAA correlation is appears weakened in patients ( In conclusion, SZ is a heterogeneous disease with various abnormal metabolites involving multiple biochemical pathways

Notably, treatment with ferroptosis inhibitors improved cardiac function and previous research suggests that activating or inhibiting Hmox1 can respectively enhance or reduce cardiac ferroptosis (122)

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