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PLoS ONE 19 , e0298660 (2024)

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In regard to mediating energy or glucose homeostasis, neurons of the myenteric plexus of the ENS are activated via duodenal glucose infusion 71 and by hormones released in response to nutrient sensing in the gut, such as GLP-1 from EECs and serotonin (5-HT) from enterochromaffin cells (ECs) 71,72,73,74

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5) While some associations have been observed, particularly with gout and renal diseases, evidence from Mendelian randomization studies did not consistently support a causal relationship between elevated serum urate levels and other metabolic or cardiovascular disorders