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considered electron microscopy characteristics of the urothelium and demonstrated defects in umbrella cells (denudation, increased pleomorphism, and decreased microplicae of the cell membrane) in patients with IC/BPS (diagnosed using ESSIC 2008 criteria) compared with controls

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DOI: org/10.1161/01.RES.79.6.1143 13

For example, PARP1 binds a DNA single strand break, then utilizes NAD + to ADP-ribosylate macromolecules in the vicinity, a signal for recruitment of DNA repair machinery 6