Those treated with an SGLT2i were more than twice as likely to develop a UTI or pyelonephritis than those treated with a GLP-1 RA (RR 2.27 [95% CI 1.12, 4.55] p =0.019)
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This treatment successfully induced cellular senescence, marked by increased SA--gal activity
Most published research protocols run the lean stack protocol for 12 to 16 weeks, followed by a 4 to 6-week off period
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At Alloy, we start there by pairing menopause-informed care with physician-guided GLP-1 treatment, personalized dosing, and longitudinal support so weight is treated as part of a broader metabolic and hormonal picture. When women in menopause see weight gain, it is often accompanied by insulin resistance, changes to lipid profiles and more inflammation systemically