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While additional studies are needed to determine whether elevated vitamin B 12 status may be related to cancer development, including evaluating whether it might be a potential marker of cancer, it is important for observational studies to adequately control for potential confounders, such as age, menopausal status, alcohol use, and intake of the B-vitamin folate

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The clinical evidence base supports its use as a tool for maintaining antioxidant status, supporting liver and immune function, and reducing oxidative burden, particularly in individuals whose endogenous production is compromised by age, chronic stress, illness, or inadequate nutrient precursor availability

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Spironolactone directly inhibits proliferation of cultured human facial sebocytes and acts antagonistically to testosterone and 5 alpha-dihydrotestosterone in vitro

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