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Despite their limited number, neurons in the caudal brainstem that synthesize GLP-1 have widely-branching axons that innervate multiple brain regions where GLP-1R is expressed, Rinaman noted

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This compound was positively identified in the plasma of 77% of the patients in our reference population, whereas for most organic acidemia patients, 3-MH was undetectable (73% of patients) or well below the median value for the reference population, thus suggesting compliance with a meat-restricted diet for the majority of subjects (Table 1)