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10.5114/aoms.2015.53304 58 SongW

One proposed mechanism is the activation of matrix metalloproteinase-9 by homocysteine, which leads to disruption of the blood-retinal barrier and increased vascular permeability in the retina [61]

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The two routes differ fundamentally in where the peptide concentrates, how predictably it reaches the bloodstream, how convenient they are, and which goals they serve best