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In the context of a herniated disc, the surrounding spinal muscles often go into a state of chronic spasm and can even atrophy from disuse or nerve signal interruption

Another widespread pollutant is N,N-diethyl-3-methylbenzamide (DEET), the most widely used insect repellent in the world

In comparison to other BV-binding photoreceptors, notably the bacteriophytochromes, the photocobilins lack the Cys residue that covalently links to the BV molecule and is essential for light-induced cis-trans isomerisation 16,17,18 (Figs