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Mechanistically, inhibition of CK2 abolished the phosphorylation of heterochromatin protein 1 (HP1), which retarded the dynamic HP1 dissociation from repressive histone mark H3K9me3 and its relocalization with H2AX to DNA damage sites, suggesting that disrupting heterochromatin remodeling in the initiation of DDR accelerates apoptosis in senescent cells

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For these individuals, microdosing may offer a way to support ongoing metabolic wellness while focusing on weight maintenance