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In addition to controlling obesity and type 2 diabetes, two key cardiovascular risk factors, GLP-1RAs may stabilise atherosclerotic plaques, mitigate post-prandial hyperlipidaemia, and reduce sympathetic nervous system activity that contributes to elevated blood pressure

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For example, ion channels such as the potassium channel Kir4.1 and the water channel aquaporin-4 (AQP-4) balance CNS ionic concentration (Cabezas et al., 2014