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Activating GLP-1R improves the brains ability to cope with stress by influencing neurotransmitter release and pathways involved in the stress response, which may help reduce cognitive and emotional issues related to aging

This discovery provides an essential mechanistic blueprint to explain why patient responses vary, why weight loss eventually plateaus, and how combining treatments could extend drug efficacy

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Zawia A, Arnold ND, West L, Pickworth JA, Turton H, Iremonger J

9 Despite advancements in therapeutics, a healthy diet and exercise, with a reduction in overall caloric intake and reduced consumption of high-fat, high-fructose, and highly processed foods remain the most effective weapons in the fight against insulin resistance and diabetes

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