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What are the reported side effects
As a signal transduction molecule, GSH participates in S-glutathionylation the reversible formation of mixed disulfides between GSH and protein cysteine residues under oxidative conditions
PubMed Central, Accessed 12 Apr
Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)
Methionine then acts as a methyl-donor to a great number of reactions that need a methyl group, including the synthesis of myelin, serotonin, dopamine, noradrenalin, DNA and phospholipids
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