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doi: 10.1016/j.autrev.2010.07.016 87

Antioxidant interventions that restore glutathione activity (including selenium supplementation, which activates GPx) have demonstrated significant reductions in TPO antibodies and oxidative stress markers in clinical trials

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reported the therapeutic potential of another natural quinazoline derivative that promoted oxidative stress and increased ROS production [113]

While glutathione is generally recognized as safe (GRAS), there is a potential for side effects to occur