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Although the role of this protein remains under active investigation, it is thought to be involved in lipid metabolism, and to exert a potential protective effect against atherosclerotic disease

The trials are double blind, meaning that neither the patient nor the doctors know who got the drug and who got the placebo

Careful record-keeping of prescribing information, including quantity, frequency, and renewal requests, as required by state and federal law, is strongly advised

It is involved in the essential protection of cells mechanism

The effect is seen after 3-4 sessions

However, under conditions of oxidative stress and substrate/cofactor (like tetrahydrobiopterin, BH4) depletion during ischemia/reperfusion, eNOS can become uncoupled. In this state, it produces O 2 instead of NO