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The primary retatrutide literature includes a discovery and preclinical characterization paper in Cell Metabolism (2022), a cryo-electron microscopy structural study in Cell Discovery (2024), a phase 1b multiple-ascending-dose trial in The Lancet (2022), and phase 2 trials reported in the New England Journal of Medicine (2023), The Lancet (2023), and Nature Medicine (2024)

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This represents an improvement over the ~15% weight loss seen over a similar time period in Wegovy clinical trials, though cross trial comparisons are unreliable