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Short-chain fatty acids stimulate the migration of neutrophils to inflammatory sites

This basal medium was then augmented with a specific cocktail of small molecules: 3 M or 1 M CHIR99021 (CHIR), IDE1, 2 M Ly294002 (Ly), and 0.75 M PD0332991 (PD)

The compound was also investigated as PL14736 in early-phase IBD clinical work, as described in a 2008 paper by Klicek and colleagues in Journal of Pharmacological Sciences , though that clinical program was never completed or approved

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They also improve metabolic liver disease