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The LEAD (Liraglutide Effect and Action Diabetes) program reported that liraglutide significantly reduced weight and improved glycated haemoglobin (HbA1c) compared to placebo/standard of care [24,25,26,27,28,29,30,31]

With a longer half-life than natural IGF-1, IGF-1 LR3 enhances lean muscle mass growth by stimulating satellite cell activation, promoting hyperplasia (the creation of new muscle fibers), and increasing protein synthesis

Metabotropic glutamate receptor 1 (mGlu1R) is expressed in T cells, when stimulated by glutamate released by DCs in the microenvironment, mediates enhanced T cell proliferation and secretion of Th1 and proinflammatory cytokines

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