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W.KronerA.BendszusM.LederC.KobsarI.FischerS.et al

This coordinated regulation of shared host metabolic and gut microbial biomarkers provides a scientific rationale for applying DSS as a multi-targeted agent, illustrating a molecular basis for a shared therapeutic approach

Although several natural compounds have entered preclinical or early clinical trials, the transition from bench to bedside is often hindered by limited pharmacokinetic stability, unclear mechanisms of action, and heterogeneous patient responses

These therapies are now widely utilized for the management of obesity, T2DM, and related complications (Hong et al., 2024)

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