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Starting at a lower dose and increasing gradually (dose titration) reduces the intensity of these effects significantly

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Step therapy requires a documented trial of metformin plus one additional agent which may include a sulfonylurea, SGLT2 inhibitor, or a preferred GLP-1 such as Ozempic or Trulicity

It enhances first and second-phase insulin secretion and reduces glucagon levels, both in a glucose dependent manner

Sex differences in the association between cardiovascular diseases and dementia subtypes: a prospective analysis of 464,616 UK Biobank participants