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Abstract Cardiovascular-Renal-Hepatic-Metabolic (CRHM) syndrome characterizes a complex, interrelated disease framework that encompasses cardiovascular disease, chronic kidney disease (CKD), metabolic dysfunction-associated steatotic liver disease, and metabolic disorders such as obesity, type 2 diabetes mellitus, dyslipidemia, and hypertension

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Second, a reduction in tubular reabsorption of both free carnitine and acylcarnitine has been reported during VPA treatment [45, 46], Third, VPA reduces endogenous synthesis of carnitine by blockade of the enzyme butyrobetaine hydroxylase

Prostaglandin synthesis in rat brain astrocytes is under the control of the n-3 docosahexaenoic acid, released by group VIB calcium-independent phospholipase A2

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Louis, MO, USA) as well as a single control incubated with the reducing agent -mercaptoethanol (Thermo Scientific, Stockholm, Sweden)