GLP-1 receptor agonists like semaglutide and tirzepatide activate hunger-suppressing brain pathways and slow stomach emptying, creating dual mechanisms for sustained weight loss
This is higher than other GLP-1s, which had discontinuation rates of 6.1% (tirzepatide), 8.0% (semaglutide) and 10.3% (orforglipron)
S.DeshpandeP
she lost a bunch of weight, but then decided she wanted to lose more and went on Mounjaro and got down to the weight she really wanted to reach
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Murine functional imaging In vivo calcium imaging (GCaMP6, GCaMP7, GCaMP8 via AAV) with miniaturised microscope or two-photon