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Patients who discontinue their medication tend to regain a significant portion of the lost weight within 12 months, as the biological signals that drive appetite and weight regain return

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Weight often starts to return within months

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The good news is that smokers melanosis can gradually fade if the person quits using tobacco products, though complete resolution may take months or years

One possibility is that hyaluronic acid binds to elastic fibres and prevents them from attack by elastase