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5 Likes KarlT February 20, 2023, 7:58am #7 I think the concern is that the percent of muscle loss is considerably higher when using this drug

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Triple-Hormone-Receptor Agonist Retatrutide for Obesity Phase 2 Trial (NEJM 2023)PubMed 2023 TRIUMPH-1: Phase 3 study of LY3437943 in adults with obesityClinicalTrials.gov 2024 Retatrutide is an investigational drug currently in Phase 3 clinical trials

This paper attempts to explain, from a food science perspective, the mechanisms by which erythritol and xylitol affect these hormones and discusses their potential implications for appetite regulation and metabolic health

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Wang G, Gao S, Su N, Xu J, Fu D