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Standard recommendations suggest treatment periods followed by equivalent rest periods

When to reassess If GI symptoms worsen instead of improving over the first 2-3 weeks of a step, if you cannot keep food down, or if you have severe persistent abdominal pain (especially with back radiation), pause and consult a qualified clinician

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[10] The first amylin analogue to reach the clinic, pramlintide, demonstrated that the pathway could be drugged, but native-style amylin analogues are short-acting and were used as multiple-daily injections, which limited their appeal for weight management

The link to autoimmune disease is leaky gut and many patients with MTHFR polymorphisms have imbalanced microbes in the gut which lead to dysbiosis and autoimmune disease -you can read more about that link here My husband and I are both negative for C677T, but both hetero for A1298C