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In cancer cells, GPT2 has been shown to couple increased glycolytic flux to increased glutamine catabolism in order to support the additional metabolic needs of the cells (Smith et al, 2016)

Calabrese V, Di Maio A, Marino G, Cardinale A, Natale G, De Rosa A, Campanelli F, Mancini M, Napolitano F, Avallone L et al (2020) Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia

Another study by Pickart et al

Bauer AZ, Kriebel D, Herbert MR, Bornehag CG, Swan SH

We provide summaries of the public comments, and our responses are set forth in the various sections of this final rule with comment period under the appropriate headings