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Unlike GHK-Cu, which occurs naturally in the human body and has broad skin research behind it, AHK-Cu was designed with hair biology in mind - particularly its potential to interact with the Wnt/-catenin signalling pathway involved in hair follicle cycling

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Activates ERK1/2 and AKT pathways via growth factor receptor upregulation

Comment: A commenter supported HCPCS code C7989 remaining in a New Technology APC but requested that HCPCS C7989 remain assigned to New Technology APC 1559 (New TechnologyLevel 22 ($2001-$2500))

Because it competes at the nicotinamide substrate site rather than the SAM cofactor site, it is also used as the substrate-competitive reference compound against which bisubstrate and covalent NNMT inhibitors are benchmarked

CNS Penetrant: Crosses the blood-brain barrier in preclinical models