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Long-term orexigenic effects of AgRP-(83132) involve mechanisms other than melanocortin receptor blockade

DSIP cortisol modulation may represent a targeted intervention at that upstream root cause one that sits outside the reach of diet, exercise, or conventional metabolic medications

Notably, both gender groups demonstrated the potential for AE development beyond the one-year treatment threshold, underscoring the importance of sustained pharmacovigilance throughout the treatment course

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References Stanczyk, FZ, et al