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These extremely rare side effects include: Reactive thrombocytosis during the first week of use in megaloblastic anaemia Hypersensitivity reactions including: rash, itching, exanthema, antibodies to HYDR0XOCOBALAMIN-transcobalamin II Anaphylaxis Hypokalaemia Headache, paraesthesia, tremor Irregular heartbeat (arrhythmias secondary to hypokalaemia) Nausea Vomiting Diarrhoea Fever, chills, hot flushes, dizziness, malaise, pain and / or swelling at the injection site Acne Abnormal colouration of the urine (chromaturia) What should you not do after a B12 shot

2500 mcg per mL / 100 units = 25 mcg/unit

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Its absorption and excretion depend on organic cation transporters: OCT1 mediates hepatic uptake, OCT2 mediates renal uptake, and MATE1/MATE2-K mediate tubular secretion [7]

However very little information is currently available that clearly links the immunogenic risk of aggregates found in modern day therapeutics using recombinant processes and manufacturing techniques