Wegovy and tirzepatide medications mimic GLP-1 (glucagon-like peptide 1), but tirzepatide also mimics GIP
Counterintuitively, increasing calories slightly, particularly from protein, sometimes breaks plateaus by restoring metabolic rate
Abbreviations DPP-4: Dipeptidyl peptidase-4 GLP-1: Glucagon-like peptide-1 iNKT: Invariant natural killer T PASI: Psoriasis Area and Severity Index Th: T helper References Davidovici BB, Sattar N, Prinz JC et al (2010) Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions
PMID 11869585
A significant reduction was observed for Mcp-1 and I-cam expression levels only in the early non-diabetic tirzepatide group, whereas Il-6 and Cd68 levels did not show statistically significant differences across the treatment groups
These mechanisms lead to improved glycaemic control and, commonly, significant weight loss