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Addgene), and 11.7 g sgRNA library using 145 g PEI (Sigma-Aldrich) in serum-free DMEM

Randomization was used for all animal experiments

Additionally, isobavachin (derived from Pittosporum species) acts as a human urate transporter 1 (hURAT1) inhibitor, blocking urate reabsorption to reduce SUA levels, akin to the mechanism of tranilast ( 3.4.3 Exploratory non-pharmacological approaches Non-pharmacological approaches serve as essential adjuncts for hyperuricemia management, particularly in asymptomatic individuals (Paul et al., 2017

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Effect of testosterone on muscle mass and muscle protein synthesis

Regulatory oversight of clinical trials in the UK is managed by the MHRA in conjunction with the Health Research Authority (HRA)