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Hormesis: Beneficial adaptations to low-dose stress like heat, cold, or fasting

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Mutat Res 480481:23141 Wondrak GT, Cabello CM, Villeneuve NF, Zhang S, Ley S, Li Y, Sun Z, Zhang DD (2008) Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress

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Unlike native IGF-1, this analog features a 13-amino acid N-terminal extension and an arginine substitution at position 3, conferring reduced affinity for insulin-like growth factor binding proteins (IGFBPs) and thus increased biological activity across multiple experimental models

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