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However, when the cell detects an apoptotic stimulus, such as DNA damage or metabolic stress, the intrinsic apoptotic pathway is triggered and mitochondrial cytochrome c is released into the cytosol ( c and then its translocation through permeabilized OMM

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Energy metabolites including ATP, ADP, and creatine phosphate reflect the follicular energetic status and correlate with oocyte developmental competence [229, 230]

Second, Lys105, Tyr110, Asp144 and Glu147 all stick out on the protein surface, are on top of the scaffold site and form a protein area in a 120 angle to the glutathione-scaffold site (Fig