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METABOLIC FLEXIBILITY, PLASTICITY, AND VULNERABILITY IN CANCER CELLS Cells have evolved elaborate metabolic flexibility to control cell survival, growth, and defense against oxidative stress for adaptation to ever-changing aerobic or anaerobic environments [16]

May experience symptom re-emergence when glutathione drops, but this reflects the underlying pathology, not true withdrawal

Monitoring strategies include periodic assessment of treatment response, adjustment of protocols based on outcomes, and long-term maintenance planning

III Opinions of respected authorities, based on clinical experience, descriptive studies and case reports, or reports of expert committees

Patch test first, and do not pile it on

We next repeated this experimental paradigm in Gipr hypo-KO and Gipr hypo-GFP mice, combining the initiation of HFD with a combination of LIRA (or VEH) alone or LIRA (or VEH) plus GIPR antagonist peptide (GIPR-antag)