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Safety, Side Effects, and Long-Term Sustainability GLP-1 medications carry well-documented side effects during dose escalation, including nausea, constipation, and mild gastrointestinal upset

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Excretion Pathways Radiolabeled studies in humans established PT-141s elimination pathways: 64.8% of administered dose recovered in urine 22.8% of dose recovered in feces Complete elimination occurring within several days No evidence of accumulation with repeated administration The predominantly renal excretion pattern and absence of accumulation support the approved dosing regimen of no more than one dose per 24 hours and maximum eight doses per month