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Eric Topol (30:55): Well, what's interesting is we're pretty close friends, and he, not only that paper you mentioned on organ clocks, which is a phenomenal contribution, but he has a paper coming out soon in Nature Medicine, the preprint is up, and what he showed was that the brain and the immune system was the main organ clocks that were associated with longevity

35 , e3158 (2019)

So, at least in these doses (more than twice the Institute of Medicine recommendation), there appears to be no additional health benefit

Science 334 , 806809, (2011)

Weeks 17-24 (12mg maintenance): Full maintenance dose