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Abbreviations: Akt protein kinase B, CFR, coronary flow reserve

Whats clear in both these graphs is the reduced steady state average, compared to seven days dosing

Pharmacol Ther 251 , 108549 (2023)

The peptide's enhancement of antioxidant enzyme activity and reduction of pro-inflammatory cytokines provides cellular protection crucial for maintaining cognitive function during aging

21 If you have reduced HNMT activity, you're more likely to accumulate intracellular histamine, which means even if your DAO is working fine in the gut, you may still have problems clearing histamine in your brain (contributing to brain fog, nervousness, sleep issues) and airways (contributing to respiratory symptoms)

In that sense, the peptide is able to treat the source of the issue rather than the symptoms alone