When to seek medical review Numbness, tingling, weakness, shortness of breath, chest pain, severe fatigue, unexplained weight loss, or neurological symptoms should be discussed with a GP or urgent service as appropriate
A side effect is an unwanted reaction that can occur during use (e.g., temporary nausea or a headache), which is often manageable by adjusting the dose and is not a pre-existing barrier to use
Across the SURPASS phase 3 programme versus placebo and active comparators, including semaglutide, tirzepatide has shown superior dose-dependent reductions in HbA1c levels up to 2.5% and body weight up to 13%, compared with all comparators [88-91]
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Dermatologic studies employed concentrations that yielded skin benefits without significant toxicity
These molecules have been shown to encourage the formation of new functional synaptic connections, induce long-term potentiation and augment memory consolidation and retrieval in animal models of AD
