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Whereas the dose plays a role, the 7-day half-life of T 4 allows physiologic compensation, such as the suppression of T 4 to T 3 conversion, inhibition of endogenous hormone production by negative feedback loops, and downregulation of thyroid hormone receptors

doi: 10.1037 [DOI] [PubMed] [Google Scholar] 24.Kang KW, Christian JC, Norton JA., Jr Heritability estimates from twin studies

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