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For now, tirzepatide is licensed for use in type 2 diabetes and obesity management, and wider approval specifically for prediabetes is still under investigation

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This is not a dismissal of the compound

Across all studies, approximately 1066 participants are involved, with enrollment ranging from smaller pilot studies involving 3070 participants to larger trials enrolling over 100 participants, with some phase III trials reaching as high as 188 participants

Researchers have yet to examine strategies to preserve or increase muscle mass during weight loss induced by GLP-1 drugs

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