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Consistent with this, our preclinical work uncovered that TMAO primed renal fibroblasts for conversion to myofibroblasts, the primary collagen-producing cells in the kidney 46 , and contributed to renal fibrosis, a hallmark of kidney damage irrespective of the underlying cause that significantly contributes to eGFR decline 46

Targeted depletion of these macrophage subsets effectively prevented the development of injury-induced chronic pain, highlighting their critical role in pain pathogenesis (208)

It has been a subject of interest in preclinical and animal studies related to sexual dysfunction, performance, and behavioral stimulation

PMID: 10642559

The BRAT diet (bananas, rice, applesauce, toast) works here

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