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Many oxidative electrophilic PTMs (e.g., cysteine oxidation at Cys151, Cys273 and Cys288) promote Nrf2 activation, leading to antioxidant gene induction, reduced ROS burden and limited TXNIP released from TRX thereby suppressing NLRP3 assembly

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Metformin and simvastatin regulate energy metabolism Within the cell, the normal maintenance of mitochondrial membrane potential is crucial for the cells survival and function

Staying hydrated is also crucial, as water helps the digestive system manage the slower transit time