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The Hostynek and Maibach group at UCSF measured exactly this in 2011: human skin permeation of GHK-Cu as a function of skin layer, with the result that the peptide accumulates in the upper stratum corneum but does not pass through to viable epidermis or dermis in any meaningful quantity 4

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It has also been explored for its potential to aid in wound healing

Plasma levels of GHK-Cu decline with age

SLC7A11 overexpression boosted cardiac GSH levels and reduced cardiac ferroptosis and injury in cardiomyopathy caused by loss of cardiac ferritin H (Fth MCK/MCK ) [76]

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