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For example, CP31398 induced apoptosis in A431 cells expressing mutant p53 but not in normal human epidermal keratinocytes (NHEKs) expressing wild-type p53

However, the majority of the scientific literature remains preclinical, meaning most studies have been conducted in animal models rather than human clinical trials

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The adduction reactions of malonaldehyde and 4-HO-nonenal with protein evolve to stable advanced lipid peroxidation products (Sayre et al., 1999) and protein carbonyls (Nair et al., 2007

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