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Also, in the presynaptic neuron, palmitoylation of SNAP-25 directs it to partition in the cell membrane [17] and allows the SNARE complex to dissociate during vesicle fusion

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Its most well-characterized mechanism involves stimulating collagen and glycosaminoglycan synthesis in skin fibroblasts, which underlies its effects on skin elasticity, firmness, and wound repair

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However, the complex, multi-dimensional and multi-stakeholder nature of the mechanism poses challenges in the operationalisation processes that have been widely criticised for failing to address local needs and exacerbating environmental and social inequalities