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When you take B12 orally, it has to survive your digestive system, and only a fraction of it may actually reach your bloodstream

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[2] Phenobarbital is metabolized by CYP2C9 and 2C19, which may lead to drug-drug interactions

Lukes Family Medicine Residency Program in Bethlehem, PA, provide a good overview of B12 deficiency recovery and the expected time it usually takes: Table 4 lists the usual times until improvement for abnormalities associated with vitamin B12 deficiency

Patients report feeling fundamentally different in their baseline energy, mental sharpness, physical resilience, and overall vitality