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"Not knowing if it is safe and being unsafe are not necessarily the same," says Carmella Britt, DVM, veterinarian at Care First Animal Hospital in Raleigh, NC, diplomate of the American College of Veterinary Sports Medicine and Rehabilitation

This pattern suggests continuous daily Dihexa administration beyond 4-6 weeks without rest periods would likely trigger protective receptor downregulation, reducing compound effectiveness over time

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Benefit is most clearly supported for athletes with clinical dehydration or documented electrolyte depletion following extreme exertion

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doi: 10.3389/fimmu.2018.01605 422 JohnstonSCStainesDRMarshall-GradisnikSM