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& Arturi, F

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The medications effects on appetite signaling and digestion are dose-dependent, meaning they become more pronounced as the dose goes up

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Treatment duration varies based on individual response, tolerability, and treatment goals, though many patients require long-term or indefinite therapy to maintain benefits

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[23] This typically manifests as mild to moderate queasiness that may be more pronounced after meals

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Its long-acting nature reduces the risk of hypoglycemia, which has led to its gradual replacement by second-generation products such as glipizide and gliquidone

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