Clinical data shows that gradual introduction at this dose level leads to better long-term tolerability and compliance
A recent paper by Langer and colleagues is important because it tried to move beyond DXA-only thinking
Not better, just different
This article explores the different kinds of B12 supplementation, why one might be preferable over the other, and if there are any extra benefits or risks depending on that choice
For example, a retrospective cohort study reported that adults receiving semaglutide (Wegovy/Ozempic, Novo Nordisk) as a type 2 diabetes or obesity medication had lower risk for suicidal ideation than those using a drug that is not a GLP-1 receptor agonist
12, 25, 26 It has been also been claimed that GLP-1 may pass the bloodbrain barrier even outside these leaks, 26 but it is currently unknown to what extent this route may be involved in signaling from the gut to the brain